TABLE OF CONTENTS
Introduction 3
Acknowledgments 8
Part I: Genesis of the theory 10
I.1 Paradigms and anomalies 10
I.2 Speculations and terminology 17
I.3 Models of immune network 25
I.4 Jerne’s reflections 30
I.5 Relationship to Jean Lindenmann 35
I.6 The theory’s début 51
Part II: The theory develops 61
II.1 A successful proposal 61
II.2 Developments and proposals of models 67
II.3 Relationship to autopoiesis 76
II.4 Criticisms 81
Part III: Splendour and decline 96
III.1 Crowning (or maybe not) 96
III.2 Jerne and the philosophers 104
III.3 Contextualist models 113
III.4 Formal modelings 123
Epilogue 130
Appendices 132 A) Selection of letters concerning INT from Jerne Files at the
Kongelige Bibliotek
132
B) Tables of data from Science Citation Index 140