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Riflessioni in un microcosmo molecolare. Per la storia della teoria della rete idiotipica/Reflections in a molecular microcosm. For the history of the idiotypic network theory

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TABLE OF CONTENTS

Introduction 3

Acknowledgments 8

Part I: Genesis of the theory 10

I.1 Paradigms and anomalies 10

I.2 Speculations and terminology 17

I.3 Models of immune network 25

I.4 Jerne’s reflections 30

I.5 Relationship to Jean Lindenmann 35

I.6 The theory’s début 51

Part II: The theory develops 61

II.1 A successful proposal 61

II.2 Developments and proposals of models 67

II.3 Relationship to autopoiesis 76

II.4 Criticisms 81

Part III: Splendour and decline 96

III.1 Crowning (or maybe not) 96

III.2 Jerne and the philosophers 104

III.3 Contextualist models 113

III.4 Formal modelings 123

Epilogue 130

Appendices 132 A) Selection of letters concerning INT from Jerne Files at the

Kongelige Bibliotek

132

B) Tables of data from Science Citation Index 140

Riferimenti

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