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BRCA2 e carcinoma prostatico

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BRCA e Carcinoma della prostata

Giuseppe Procopio, MD Istituto Nazionale Tumori

Milano

(2)
(3)

Slide 4

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(4)

International Stand Up to Cancer- PCF Prostate Cancer Dream Team

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(5)

Implications of homologous recombination alterations:

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(6)

Homologous recombination (HR): open questions

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(7)

4. Nuovi Target

(8)

4. Nuovi Target

(9)

• HRR mutation status was not used for stratification

• Similar benefit regardless of HRR mutation status

• Study was not powered for subgroup analyses

4. Nuovi Target

(10)

Slide 11

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(11)

AR signaling is still the major driver of CRPC

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(12)

Strategies to better target the AR

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(13)

Are there tumors that are more resistant to AR pathway inhibition (AR independent)?

Presented By Himisha Beltran at 2019 Genitourinary Cancers Symposium

(14)

Conclusions

Genetic test as prevention for familiar risk group

The cost of genetic testing and counseling needs to be weighed against cost of treating late stage disease

We need to design and incorporate predictive factors into clinical trials

Real world and big data,multidisciplinary strategy translate molecular

features into a personalized approach

Riferimenti

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